Calcium carbonate carbonate is a chemical compound. It is commonly used medicinally as a calcium supplement
or as an antacid, but excessive consumption can be hazardous. Calcium in the body of an adult is about 1200 gms,
99% of this in bones and teeth and rest is in the whole body. Absorption takes place in the jejunum and partly
ileum. Found in milk and milk products, vegetables etc. Normally serum Ca level is 10 mg/ml. Serum calcium is
regulated by parathyroid hormone. Helps in formation of teeth and bones, in coagulation of blood, in neuro-mascular
transmission, regulation of membrane permeability and normal enzymetic activity. Calcium is used in osteoporosis,
steroid therapy, rickets, antacid etc. Daily requirement varies from 300 to 1200 mg in variety of patients.
Calcitrol increases the level of calcium (Ca2+) in the blood by increasing the uptake of calcium from the gut
into the blood, and increasing the release of calcium into the blood from bone.
Folic acid is essential for normal erythropoiesis process by exogenous administration. Folic acid is vital for
the biosynthesis of purines and thymidylate of nucleic acids. Folic acid is rapidly absorbed in the proximal portion
of the small intestine. After oral administration, the Cmax can be achieved within one hour. Folic acid is
well-distributed in all over the body tissues and stored in hepatic tissues. Folic acid is metabolized in liver into
dihydrofolate and tetrahydrofolate forms. About 90% of the administered dose is excreted via the urine. Daily
requirement in general is 0.2 mg.
Pyridoxine is one of the compounds that can be called vitamin B6. Pyridoxine assists in the balancing of sodium
and potassium as well as promoting red blood cell production. Pyridoxine may help balance hormonal changes in women
and aid the immune system. Lack of pyridoxine may cause anemia, nerve damage, seizures, skin problems, and sores in
the mouth. It is required for the production of the monoamine neurotransmitters serotonin, dopamine, norepinephrine
and epinephrine, as it is the precursor to pyridoxal phosphate - cofactor for the enzyme aromatic amino acid
decarboxylase. This enzyme is responsible for converting the precursors 5-hydroxytryptophan (5-HTP) into serotonin
and levodopa (L-DOPA) into dopamine, noradrenaline and adrenaline. As such it has been implicated in the treatment of
depression and anxiety. Daily requirement is 1-2 mg.
Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin a form of vitamin B12. It differs from cyanocobalamin
in that the cyano at the cobalt is replaced with a methyl group.Methylcobalamin features an octahedral cobalt(III) centre
and can be obtained as bright red crystals. methylcobalamin is equivalent physiologically to vitamin B12, and can be
used to prevent or treat pathology arising from a lack of vitamin B in peripheral neuropathy, diabetic neuropathy, and as
a preliminary treatment for amyotrophic lateral sclerosis. It is a form of vitamin B12 and differs from cyanocobalamin
in that the cyanide is replaced by a methyl group. Methylcobalamin is produced by some bacteria. It plays an important
role in the environment. Methylcobalamin is a kind of endogenous co enzyme B12. Mecobalamin plays an important role in
transmethylation as a co enzyme in the synthesis of methionine from homocysteine . Mecobalamin is well transported to
nerve cell organnells and promotes nucleic acid and protein synthesis. This medication is a cobalamin, prescribed for
peripheral neuropathy, megaloblastic anaemia, and as a preliminary treatment for amyotrophic lateral sclerosis. Peripheral
neuropathies- the recommended dose is 1,500 mcg/day in 3 divided doses.
Zinc is an essential mineral. In children it causes growth retardation, delayed sexual maturation, infection
susceptibility, and diarrhea. Zinc stimulates the activity of about 200 enzymes, maintain healthy immune system, maintains
memory, prevents premature delivery, helps AIDS patients to increase immunity, has anti-inflammatory benefits , needed for
DNA synthesis , helps normal growth and development, helps sperm production and ovulation, helps in digestion of food,
prevents hair loss and Alopecia, provides healthy nails, strengthen bone, helps to fight infection, helps in controlling
diabetes, helps acne and wound healing, is vital in protein stnthesis, helps in carrying cabon-di-oxide from the cells.
Zinc requirements Infants- 0 - 6 months: 2 milligrams per day (mg/day), 7 - 12 months: 3 mg/day /, Children: 1 - 3
years: 3 mg/day, 4 - 8 years: 5 mg/day, 9 - 13 years: 8 mg/day /Adolescents and Adults - Males age 14 and over: 11 mg/day,
Females age 14 to 18 years: 9 mg/day, Females age 19 and over: 8 mg/day.
Magnesium is found in all tissues of body. It is easily absorbed from small intestine. It plays an important role in
plasma and potassium metabolism. It is essential for neuro-muscular irritability and intracellular enzymes and carbohydrate
metabolism. Daily requirement is 300 mg.
K2 7 Vitamin comprises of vitamin K1 and vitamin K2 . Vitamin K is fat-soluble and that it has several forms. Vitamin
K is found in leafy green vegetables (e.g., lettuce, broccoli, spinach, cabbage) and vegetable oils (e.g., soybean and
canola oils). Vitamin K1 is made by plants. Vitamin K2 is made by intestinal bacteria. K2 production by bacteria provides
only a minor fraction of our daily needs since it is made mostly in the large intestine and colon where it is poorly
absorbed. Vitamin K2 is a collective term for a group of Vitamin K compounds called menaquinone. The individual components
of Vitamin K2 are also referred to by the number of isoprenyl units in the side chain; generally they are designated as
MK-n (n=1-9). Compared to the other Vitamin K analogues, Vitamin K2 7 has the most potent gamma-carboxylation activity3.
Vitamin K27 needed for optimal carboxylation of osteocalcin. Osteocalcin is synthesized only in osteoblasts. Osteocalcin
bind to hydroxyapatite for calcification. MGP (vitamin-K2 dependent-Matrix gla protein-has a high affinity binding to
calcium ions) plays a key role in the inhibition of tissue calcification. MGP needs to be carboxylated to function
properly, this carboxylation or activation is done by Vitamin K27. Vitamin K27 has a great role in Osteoporosis and
Cardiovascular health.
INDICATIONS
Osteomalacia is the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. The impairment of bone metabolism causes inadequate bone remineralization. Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones. The most common cause of osteomalacia is deficiency of vitamin D, which is normally derived from sunlight exposure and to a lesser extent, from diet.
Osteoporosis is a disease of bones that leads to an increased risk of fracture. In osteoporosis, the bone mineral density (BMD-Avg 2.5) is reduced, bone microarchitecture deteriorates, and the amount and variety of proteins in bone are altered.
Bone Health The human skeletal system is a complex organ in constant equilibrium with the rest of the body. In addition to support and structure of the body, bone is the major reservoir for many minerals and compounds essential for maintaining a healthy pH balance. The deterioration of the body with age renders the elderly particularly susceptible to and affected by poor bone health. Vitamin deficiency can cause a disease or syndrome known as an avitaminosis or hypovitaminosis. This usually refers to a long-term deficiency of a vitamin.
NOTE
Calcium balance or Serum calcium rarely deviates from its normal range and is regulated primarily by the interaction of two hormones - parathyroid hormone (PTH) from the parathyroid glands and calcitonin from specialised cells in the thyroid glands. PTH is released when blood calcium levels decline.
Bone mineral density (BMD) is the amount of bone mineral in bone tissue. The concept is of mass of mineral per volume of bone.
DOSE
One tablet once daily or as directed by the doctor.
INTRODUCTION
EACH TABLETS CONTAINS: ENGERGY 0.756 KCAL , CARBOHYDRATE 185.0 MG. 0.06% , PROTEIN 4.2 MG. 0.008% , FAT 0.00GM CALCIUM CARBONATE (FROM CORAL GRAINS) ,EQV. TO ELEMENTAL CALCIUM 225 MG. 22.5 %, CALCITRIOL 0.25 MCG , FOLIC ACID 400 MCG. 100% , VITAMIN B6 2MG. 100% . METHYLCOBALAMIN 1500 MCG, ZINC-SULPHATE MONOHYDRATE 7.5 MG. 20% , MAGNESIUM OXIDE 50MG 7.5% ,VITAMIN K27 50MCG 62.5% , EXCIPIENTS Q.S
Calcium carbonate carbonate is a chemical compound. It is commonly used medicinally as a calcium supplement or as an antacid, but excessive consumption can be hazardous. Calcium in the body of an adult is about 1200 gms, 99% of this in bones and teeth and rest is in the whole body. Absorption takes place in the jejunum and partly ileum. Found in milk and milk products, vegetables etc. Normally serum Ca level is 10 mg/ml. Serum calcium is regulated by parathyroid hormone. Helps in formation of teeth and bones, in coagulation of blood, in neuro-mascular transmission, regulation of membrane permeability and normal enzymetic activity. Calcium is used in osteoporosis, steroid therapy, rickets, antacid etc. Daily requirement varies from 300 to 1200 mg in variety of patients.
Calcitrol increases the level of calcium (Ca2+) in the blood by increasing the uptake of calcium from the gut into the blood, and increasing the release of calcium into the blood from bone.
Folic acid is essential for normal erythropoiesis process by exogenous administration. Folic acid is vital for the biosynthesis of purines and thymidylate of nucleic acids. Folic acid is rapidly absorbed in the proximal portion of the small intestine. After oral administration, the Cmax can be achieved within one hour. Folic acid is well-distributed in all over the body tissues and stored in hepatic tissues. Folic acid is metabolized in liver into dihydrofolate and tetrahydrofolate forms. About 90% of the administered dose is excreted via the urine. Daily requirement in general is 0.2 mg.
Pyridoxine is one of the compounds that can be called vitamin B6. Pyridoxine assists in the balancing of sodium and potassium as well as promoting red blood cell production. Pyridoxine may help balance hormonal changes in women and aid the immune system. Lack of pyridoxine may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth. It is required for the production of the monoamine neurotransmitters serotonin, dopamine, norepinephrine and epinephrine, as it is the precursor to pyridoxal phosphate - cofactor for the enzyme aromatic amino acid decarboxylase. This enzyme is responsible for converting the precursors 5-hydroxytryptophan (5-HTP) into serotonin and levodopa (L-DOPA) into dopamine, noradrenaline and adrenaline. As such it has been implicated in the treatment of depression and anxiety. Daily requirement is 1-2 mg.
Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin a form of vitamin B12. It differs from cyanocobalamin in that the cyano at the cobalt is replaced with a methyl group.Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. methylcobalamin is equivalent physiologically to vitamin B12, and can be used to prevent or treat pathology arising from a lack of vitamin B in peripheral neuropathy, diabetic neuropathy, and as a preliminary treatment for amyotrophic lateral sclerosis. It is a form of vitamin B12 and differs from cyanocobalamin in that the cyanide is replaced by a methyl group. Methylcobalamin is produced by some bacteria. It plays an important role in the environment. Methylcobalamin is a kind of endogenous co enzyme B12. Mecobalamin plays an important role in transmethylation as a co enzyme in the synthesis of methionine from homocysteine . Mecobalamin is well transported to nerve cell organnells and promotes nucleic acid and protein synthesis. This medication is a cobalamin, prescribed for peripheral neuropathy, megaloblastic anaemia, and as a preliminary treatment for amyotrophic lateral sclerosis. Peripheral neuropathies- the recommended dose is 1,500 mcg/day in 3 divided doses.
Zinc is an essential mineral. In children it causes growth retardation, delayed sexual maturation, infection susceptibility, and diarrhea. Zinc stimulates the activity of about 200 enzymes, maintain healthy immune system, maintains memory, prevents premature delivery, helps AIDS patients to increase immunity, has anti-inflammatory benefits , needed for DNA synthesis , helps normal growth and development, helps sperm production and ovulation, helps in digestion of food, prevents hair loss and Alopecia, provides healthy nails, strengthen bone, helps to fight infection, helps in controlling diabetes, helps acne and wound healing, is vital in protein stnthesis, helps in carrying cabon-di-oxide from the cells. Zinc requirements Infants- 0 - 6 months: 2 milligrams per day (mg/day), 7 - 12 months: 3 mg/day /, Children: 1 - 3 years: 3 mg/day, 4 - 8 years: 5 mg/day, 9 - 13 years: 8 mg/day /Adolescents and Adults - Males age 14 and over: 11 mg/day, Females age 14 to 18 years: 9 mg/day, Females age 19 and over: 8 mg/day.
Magnesium is found in all tissues of body. It is easily absorbed from small intestine. It plays an important role in plasma and potassium metabolism. It is essential for neuro-muscular irritability and intracellular enzymes and carbohydrate metabolism. Daily requirement is 300 mg.
K2 7 Vitamin comprises of vitamin K1 and vitamin K2 . Vitamin K is fat-soluble and that it has several forms. Vitamin K is found in leafy green vegetables (e.g., lettuce, broccoli, spinach, cabbage) and vegetable oils (e.g., soybean and canola oils). Vitamin K1 is made by plants. Vitamin K2 is made by intestinal bacteria. K2 production by bacteria provides only a minor fraction of our daily needs since it is made mostly in the large intestine and colon where it is poorly absorbed. Vitamin K2 is a collective term for a group of Vitamin K compounds called menaquinone. The individual components of Vitamin K2 are also referred to by the number of isoprenyl units in the side chain; generally they are designated as MK-n (n=1-9). Compared to the other Vitamin K analogues, Vitamin K2 7 has the most potent gamma-carboxylation activity3. Vitamin K27 needed for optimal carboxylation of osteocalcin. Osteocalcin is synthesized only in osteoblasts. Osteocalcin bind to hydroxyapatite for calcification. MGP (vitamin-K2 dependent-Matrix gla protein-has a high affinity binding to calcium ions) plays a key role in the inhibition of tissue calcification. MGP needs to be carboxylated to function properly, this carboxylation or activation is done by Vitamin K27. Vitamin K27 has a great role in Osteoporosis and Cardiovascular health.
Osteomalacia is the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. The impairment of bone metabolism causes inadequate bone remineralization. Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones. The most common cause of osteomalacia is deficiency of vitamin D, which is normally derived from sunlight exposure and to a lesser extent, from diet.
Osteoporosis is a disease of bones that leads to an increased risk of fracture. In osteoporosis, the bone mineral density (BMD-Avg 2.5) is reduced, bone microarchitecture deteriorates, and the amount and variety of proteins in bone are altered.
Bone Health The human skeletal system is a complex organ in constant equilibrium with the rest of the body. In addition to support and structure of the body, bone is the major reservoir for many minerals and compounds essential for maintaining a healthy pH balance. The deterioration of the body with age renders the elderly particularly susceptible to and affected by poor bone health. Vitamin deficiency can cause a disease or syndrome known as an avitaminosis or hypovitaminosis. This usually refers to a long-term deficiency of a vitamin.
Calcium balance or Serum calcium rarely deviates from its normal range and is regulated primarily by the interaction of two hormones - parathyroid hormone (PTH) from the parathyroid glands and calcitonin from specialised cells in the thyroid glands. PTH is released when blood calcium levels decline.
Bone mineral density (BMD) is the amount of bone mineral in bone tissue. The concept is of mass of mineral per volume of bone.
One tablet once daily or as directed by the doctor.