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INTRODUCTION

LEVOFLOXACIN HEMIHYDRATE I.P. EQV. TO LEVOFLOXACIN 500MG. EXCIPIENTS Q.S

  • Levofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase iv which is an enzyme necessary to separate replicated DNA, thereby inhibiting cell division. The fluoroquinolones interfere with DNA replication by inhibiting an enzyme complex called DNA gyrase. This can also affect mammalian cell replication.

  • INDICATIONS

    Acute Bacterial Sinusitis

    Sinus is a sac or cavity in any organ or tissue Types of Sinuses are - Paranasal sinuses, air cavities in the cranial bones, especially those near the nose, including-Maxillary sinus(is the largest of the paranasal sinuses, under the eyes, in the maxillary bones),Frontal sinus(superior to the eyes, in the frontal bone, which forms the hard part of the forehead),Ethmoid sinus(formed from several discrete air cells within the ethmoid bone between the eyes and under the nose),Sphenoidal sinus(in the sphenoid bone at the center of the skull base under the pituitary gland),Anal sinuses (the furrows which separate the columns in the rectum),Dural venous sinuses(venous channels found between layers of dura mater in the brain).

    Sinusitis, also known as a sinus infection or rhinosinusitis, is inflammation of the sinuses resulting in symptoms. Common signs and symptoms include thick nasal mucus, a plugged nose, and pain in the face. Other signs and symptoms may include fever, headaches, poor sense of smell, sore throat, and cough. Complicated Urinary Tract Infection is urinary tract infection (UTI) is an infection that affects part of the urinary tract When it affects the lower urinary tract it is known as a bladder infection (cystitis) and when it affects the upper urinary tract it is known as kidney infection (pyelonephritis). Symptoms from a lower urinary tract include pain with urination, frequent urination, and feeling the need to urinate despite having an empty bladder. The most common cause of infection is Escherichia coli, though other bacteria or fungi may rarely be the cause.

    Community-acquired pneumonia (CAP) refers to pneumonia (any of several lung diseases) contracted by a person with little contact with the healthcare system. The chief difference between hospital-acquired pneumonia (HAP) and CAP is that patients with HAP live in long-term care facilities or have recently visited a hospital and CAP is common.

    Chronic bronchitis or Chronic obstructive pulmonary disease (COPD) ) is a type of obstructive lung disease characterized by long-term poor airflow. The main symptoms include shortness of breath and cough with sputum production.

    Uncomplicated Skin and soft tissue infection (USSTI) also is an infection of skin and associated soft tissues (such as loose connective tissue and mucous membranes). The pathogen involved is usually a bacterial species. Such infections often requires treatment by antibiotics. "Uncomplicated" SSSIs included simple abscesses, impetiginous lesions, furuncles, and cellulitis. USSTI is normally only caused by Staphylococcus aureus and Streptococcus pyogenes.

    Chronic bacterial prostatitis is a bacterial infection of the prostate gland. It should be distinguished from other forms of prostatitis such as acute bacterial prostatitis and chronic pelvic pain syndrome (CPPS).

  • NOTE

    Pneumonia caused by Legionella , Streptococcus pneumoniae , Klebsiella , Mycoplasma pneumonia. Uropathogen is E.Coli.

  • DOSE

    One tablet once daily for 7 days or as directed by the doctor.

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