EACH 40 TAB CONTAINS: PANTOPRAZOLE SODIUM I.P. EQV. TO PATOPRAZOLE 40MG. AND DSR CONTAINS: PANTOPRAZOLE SODIUM I.P. EQV. TO PATOPRAZOLE
40MG (AS ENTERIC COATED PELLETS)+ DOMPERIDONE I.P. 30MG.(AS SUSTAINED RELEASE PELLETS) EXCIPIENTS Q.S.
Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. Pantoprazole is metabolized
in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by
sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole is relatively free of drug interactions.
Pantoprazole binds irreversibly to H+K+ATPase(Proton pumps) and suppresses the secretion of acid. As it binds
irreversibly to the pumps, new pumps have to be made before acid production could be resumed. The drug's plasma
half-life is about 2 hours.
Domperidone is an antidopaminergic drug, as a prokinetic agent and for promoting lactation. Domperidone blocks
the action of dopamine. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the
chemoreceptor trigger zone, located just outside the blood brain barrier, which, among others, regulates nausea
and vomiting.
INDICATIONS
GERD is Gastro Esophageal Reflux Disease.
H.Pylori Infection or Helicobacter pylori previously named Campylobacter pyloridis, is a Gram-negative,
microaerophilic bacterium found in the stomach. It was identified in patients with chronic gastritis and gastric ulcers,
conditions that were not previously believed to have a microbial cause. It is also linked to the development of duodenal
ulcers and stomach cancer
Peptic ulcer disease (PUD), also known as a peptic ulcer or stomach ulcer, is a break in the lining of the stomach,
first part of the small intestine, or occasionally the lower esophagus. An ulcer in the stomach is known as a gastric
ulcer while that in the first part of the intestines is known as a duodenal ulcer.
Zollinger-Ellison Syndrome is a triad of gastric acid hypersecretion, severe peptic ulceration, and non-beta cell
islet tumour of pancreas (gastrinoma).
NOTE
Proton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system
(the H+/K+ ATPase, or, more commonly, the gastric proton pump) of the gastric parietal cells. The proton pump is the
terminal stage in gastric acid secretion, being directly responsible for secreting H+ ions into the gastric lumen, making
it an ideal target for inhibiting acid secretion. Targeting the terminal step in acid production, as well as the
irreversible nature of the inhibition, results in a class of drugs that are significantly more effective than H2
antagonists and reduce gastric acid secretion by up to 99%. Decreasing the acid in the stomach can aid the healing of
duodenal ulcers and reduce the pain from indigestion and heartburn. Stomach acids are needed however to digest proteins,
vitamin B12, calcium, and other nutrients. Too little stomach acid causes the condition hypochlorhydria . The PPIs are
given in an inactive form, which is neutrally charged (lipophilic) and readily crosses cell membranes into intracellular
compartments (like the parietal cell canaliculus) with acidic environments. In an acid environment, the inactive drug is
protonated and rearranges into its active form. As described above, the active form will covalently and irreversibly bind
to the gastric proton pump, deactivating it.
DOSE
One tablet once or twice daily or as directed by the doctor.
INTRODUCTION
EACH 40 TAB CONTAINS: PANTOPRAZOLE SODIUM I.P. EQV. TO PATOPRAZOLE 40MG. AND DSR CONTAINS: PANTOPRAZOLE SODIUM I.P. EQV. TO PATOPRAZOLE 40MG (AS ENTERIC COATED PELLETS)+ DOMPERIDONE I.P. 30MG.(AS SUSTAINED RELEASE PELLETS) EXCIPIENTS Q.S.
Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. Pantoprazole is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole is relatively free of drug interactions. Pantoprazole binds irreversibly to H+K+ATPase(Proton pumps) and suppresses the secretion of acid. As it binds irreversibly to the pumps, new pumps have to be made before acid production could be resumed. The drug's plasma half-life is about 2 hours.
Domperidone is an antidopaminergic drug, as a prokinetic agent and for promoting lactation. Domperidone blocks the action of dopamine. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which, among others, regulates nausea and vomiting.
GERD is Gastro Esophageal Reflux Disease.
H.Pylori Infection or Helicobacter pylori previously named Campylobacter pyloridis, is a Gram-negative, microaerophilic bacterium found in the stomach. It was identified in patients with chronic gastritis and gastric ulcers, conditions that were not previously believed to have a microbial cause. It is also linked to the development of duodenal ulcers and stomach cancer
Peptic ulcer disease (PUD), also known as a peptic ulcer or stomach ulcer, is a break in the lining of the stomach, first part of the small intestine, or occasionally the lower esophagus. An ulcer in the stomach is known as a gastric ulcer while that in the first part of the intestines is known as a duodenal ulcer.
Zollinger-Ellison Syndrome is a triad of gastric acid hypersecretion, severe peptic ulceration, and non-beta cell islet tumour of pancreas (gastrinoma).
Proton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H+/K+ ATPase, or, more commonly, the gastric proton pump) of the gastric parietal cells. The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H+ ions into the gastric lumen, making it an ideal target for inhibiting acid secretion. Targeting the terminal step in acid production, as well as the irreversible nature of the inhibition, results in a class of drugs that are significantly more effective than H2 antagonists and reduce gastric acid secretion by up to 99%. Decreasing the acid in the stomach can aid the healing of duodenal ulcers and reduce the pain from indigestion and heartburn. Stomach acids are needed however to digest proteins, vitamin B12, calcium, and other nutrients. Too little stomach acid causes the condition hypochlorhydria . The PPIs are given in an inactive form, which is neutrally charged (lipophilic) and readily crosses cell membranes into intracellular compartments (like the parietal cell canaliculus) with acidic environments. In an acid environment, the inactive drug is protonated and rearranges into its active form. As described above, the active form will covalently and irreversibly bind to the gastric proton pump, deactivating it.
One tablet once or twice daily or as directed by the doctor.